Taxol and 10-deacetylbaccatinIII induce distinct changes in the dynamics of caveolae.
FEBS Lett
; 582(25-26): 3595-600, 2008 Oct 29.
Article
in En
| MEDLINE
| ID: mdl-18817775
ABSTRACT
Taxol treatment of HeLa cells resulted in a transient recruitment of Caveolin-1 to the cell surface followed by internalization. Interestingly, 20min after 10-deacetylbaccatinIII (10-DAB) treatment, the caveolae displayed faster 'kiss and run' dynamics while BaccatinIII (BacIII) did not induce any change. Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB, the former shows phosphorylated Raf-1, ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same. BacIII treatment did not induce phosphorylation of Raf-1 or Bcl-2. It is possible that Taxol might act on multiple targets and the side chain may be crucial.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paclitaxel
/
Caveolae
/
Taxoids
/
Caveolin 1
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
FEBS Lett
Year:
2008
Document type:
Article