Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.

Vendeville, Sandrine; Nilsson, Magnus; de Kock, Herman; Lin, Tse-I; Antonov, Dmitry; Classon, Björn; Ayesa, Susana; Ivanov, Vladimir; Johansson, Per-Ola; Kahnberg, Pia; Eneroth, Anders; Wikstrom, Kristina; Vrang, Lotta; Edlund, Michael; Lindström, Stefan; Van de Vreken, Wim; McGowan, David; Tahri, Abdellah; Hu, Lili; Lenz, Oliver; Delouvroy, Frederic; Van Dooren, Marleen; Kindermans, Natalie; Surleraux, Dominique; Wigerinck, Piet; Rosenquist, Asa; Samuelsson, Bertil; Simmen, Kenneth; Raboisson, Pierre

Vendeville, Sandrine; Nilsson, Magnus; de Kock, Herman; Lin, Tse-I; Antonov, Dmitry; Classon, Björn; Ayesa, Susana; Ivanov, Vladimir; Johansson, Per-Ola; Kahnberg, Pia; Eneroth, Anders; Wikstrom, Kristina; Vrang, Lotta; Edlund, Michael; Lindström, Stefan; Van de Vreken, Wim; McGowan, David; Tahri, Abdellah; Hu, Lili; Lenz, Oliver; Delouvroy, Frederic; Van Dooren, Marleen; Kindermans, Natalie; Surleraux, Dominique; Wigerinck, Piet; Rosenquist, Asa; Samuelsson, Bertil; Simmen, Kenneth; Raboisson, Pierre.

Affiliation

Vendeville S; Tibotec BVBA, Gen. De Wittelaan L11 B3, B-2800 Mechelen, Belgium.

Bioorg Med Chem Lett ; 18(23): 6189-93, 2008 Dec 01.

Article in En | MEDLINE | ID: mdl-18954982

Subject(s)

Antiviral Agents/chemical synthesis; Antiviral Agents/pharmacology; Hepacivirus/drug effects; Proline/chemical synthesis; Proline/pharmacology; Serine Proteinase Inhibitors/chemical synthesis; Serine Proteinase Inhibitors/pharmacology; Urea/analogs & derivatives; Urea/chemical synthesis; Urea/pharmacology; Viral Nonstructural Proteins/antagonists & inhibitors; Administration, Oral; Animals; Antiviral Agents/chemistry; Carbamates/pharmacology; Carbamates/therapeutic use; Combinatorial Chemistry Techniques; Drug Design; Male; Models, Molecular; Molecular Structure; Proline/analogs & derivatives; Proline/chemistry; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors/chemistry; Structure-Activity Relationship; Urea/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Urea / Proline / Serine Proteinase Inhibitors / Viral Nonstructural Proteins / Hepacivirus Limits: Animals Language: En Journal: Bioorg Med Chem Lett Year: 2008 Document type: Article

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