Analytical characterization of chitosan nanoparticles for peptide drug delivery applications.
Anal Bioanal Chem
; 393(1): 207-15, 2009 Jan.
Article
in En
| MEDLINE
| ID: mdl-18958447
ABSTRACT
Chitosan-cyclodextrin hybrid nanoparticles (NPs) were obtained by the ionic gelation process in the presence of glutathione (GSH), chosen as a model drug. NPs were characterized by means of transmission electron microscopy and zeta-potential measurements. Furthermore, a detailed X-ray photoelectron spectroscopy study was carried out in both conventional and depth-profile modes. The combination of controlled ion-erosion experiments and a scrupulous curve-fitting approach allowed for the first time the quantitative study of the GSH in-depth distribution in the NPs. NPs were proven to efficiently encapsulate GSH in their inner cores, thus showing promising perspectives as drug carriers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Drug Carriers
/
Drug Delivery Systems
/
Chitosan
/
Nanoparticles
Language:
En
Journal:
Anal Bioanal Chem
Year:
2009
Document type:
Article