Dopamine receptor D4 gene -521C/T polymorphism is associated with opioid dependence through cold-pain responses.
Ann N Y Acad Sci
; 1139: 20-6, 2008 Oct.
Article
in En
| MEDLINE
| ID: mdl-18991844
ABSTRACT
Heroin users exhibit abnormal pain sensitivity called opioid-induced hyperalgesia that may weaken their determination to abstain. The dopamine receptor D4 gene (DRD4) is associated with heroin dependence; one of its polymorphisms is a C/T variation 521 bp upstream to the gene (-521C/T). We investigated whether this polymorphism was related to opioid dependence through modulation of cold-pain responses. We recruited 84 heroin-dependent Chinese male subjects and 168 healthy male Chinese controls. Genotyping was performed by PCR-RFLP. A significantly higher T allele frequency was observed in the heroin group (P= 0.041). Of the cohort recruited, 43 current heroin users and 66 controls were further subjected to a cold-pressor test (CPT) to determine their pain threshold and tolerance. TT controls demonstrated a significantly lower pain threshold than did their CC/CT counterparts (P= 0.022) and TT opioid users (P= 0.006). Moreover, CC/CT controls had a significantly higher pain tolerance than TT controls (P= 0.042) and CC/CT opioid users (P= 0.010). The data suggest that DRD4-521C/T plays an important role in opioid dependence through modulating cold-pain responses. TT individuals might have a higher tendency to use opioids because they experience pain less strongly after chronic opioid use.
Full text:
1
Collection:
01-internacional
Health context:
2_ODS3
/
8_ODS3_consumo_sustancias_psicoactivas
Database:
MEDLINE
Main subject:
Pain
/
Polymorphism, Genetic
/
Thermosensing
/
Cold Temperature
/
Receptors, Dopamine D4
/
Heroin Dependence
Type of study:
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Ann N Y Acad Sci
Year:
2008
Document type:
Article