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Expression and hormonal regulation of IL-11Ralpha in canine uterus during early pregnancy.
Guo, B; Han, B-C; Tian, Z; Zhao, T-Y; Zeng, L; Yang, Z-M; Yue, Z-P.
Affiliation
  • Guo B; College of Animal Science and Veterinary Medicine, Jilin University, Changchun, P.R. China.
Reprod Domest Anim ; 44(5): 779-82, 2009 Oct.
Article in En | MEDLINE | ID: mdl-18992081
Embryo implantation is critical for the successful establishment of pregnancy. Interleukin-11 (IL-11) is essential for adequate decidualization in the mouse and human via binding to the specific IL-11 receptor alpha (IL-11Ralpha). But the expression and regulation of IL-11 and IL-11Ralpha in the canine endometrium remain unknown. The aim of this study was to investigate the differential expression of IL-11Ralpha in canine uterus during early pregnancy and its regulation under different conditions by in situ hybridization. Interleukin-11Ralpha mRNA was mainly localized in glandular epithelium in canine uterus. There was a low level of IL-11Ralpha expression in the glandular epithelium on days 6, 12 and 17 of pregnancy. On day 20 of pregnancy when embryo implanted, IL-11Ralpha mRNA was highly expressed in the glandular epithelium surrounding the embryo, but not in the luminal epithelium and stroma. On day 23 of pregnancy, the expression of IL-11Ralpha mRNA maintained a constant level compared with the expression of day 20 and increased on day 28 of pregnancy. During the oestrous cycle, a high level of IL-11Ralpha mRNA expression was seen in the oestrous uterus. Progesterone slightly induced the expression of IL-11Ralpha mRNA in the ovariectomized canine uterus. These results suggest that IL-11Ralpha expression is closely related to canine implantation and up-regulated by progesterone.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progesterone / Uterus / Gene Expression Regulation / Dogs / Interleukin-11 Receptor alpha Subunit Limits: Animals / Pregnancy Language: En Journal: Reprod Domest Anim Year: 2009 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progesterone / Uterus / Gene Expression Regulation / Dogs / Interleukin-11 Receptor alpha Subunit Limits: Animals / Pregnancy Language: En Journal: Reprod Domest Anim Year: 2009 Document type: Article