Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes.

Chen, Yixin; Qin, Kun; Wu, Wai Lan; Li, Guoqiang; Zhang, Jun; Du, Hailian; Ng, Mun Hon; Shih, J Wai-Kuo; Peiris, J S Malik; Guan, Yi; Chen, Honglin; Xia, Ningshao

Chen, Yixin; Qin, Kun; Wu, Wai Lan; Li, Guoqiang; Zhang, Jun; Du, Hailian; Ng, Mun Hon; Shih, J Wai-Kuo; Peiris, J S Malik; Guan, Yi; Chen, Honglin; Xia, Ningshao.

Affiliation

Chen Y; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, China.

J Infect Dis ; 199(1): 49-58, 2009 Jan 01.

Article in En | MEDLINE | ID: mdl-19032063

Subject(s)

Antibodies, Monoclonal/immunology; Epitopes/immunology; Influenza A Virus, H5N1 Subtype/immunology; Influenza Vaccines/therapeutic use; Influenza in Birds/immunology; Influenza, Human/immunology; Influenza, Human/pathology; Animals; Birds/virology; Body Weight; Chick Embryo/virology; Conserved Sequence; Cross Reactions; Hemagglutination Inhibition Tests; Humans; Influenza A Virus, H5N1 Subtype/classification; Influenza A Virus, H5N1 Subtype/genetics; Influenza A Virus, H5N1 Subtype/isolation & purification; Influenza, Human/mortality; Mice; Mice, Inbred BALB C

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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / Influenza A Virus, H5N1 Subtype / Influenza in Birds / Antibodies, Monoclonal / Epitopes Limits: Animals / Humans Language: En Journal: J Infect Dis Year: 2009 Document type: Article

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