Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.

Filosa, Rosanna; Carmela Fulco, M; Marinozzi, Maura; Giacchè, Nicola; Macchiarulo, Antonio; Peduto, Antonella; Massa, Antonio; de Caprariis, Paolo; Thomsen, Christian; Christoffersen, Claus T; Pellicciari, Roberto

Filosa, Rosanna; Carmela Fulco, M; Marinozzi, Maura; Giacchè, Nicola; Macchiarulo, Antonio; Peduto, Antonella; Massa, Antonio; de Caprariis, Paolo; Thomsen, Christian; Christoffersen, Claus T; Pellicciari, Roberto.

Affiliation

Filosa R; Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, Variante 11C, 84084 Fisciano, Italy.

Bioorg Med Chem ; 17(1): 242-50, 2009 Jan 01.

Article in En | MEDLINE | ID: mdl-19042134

Subject(s)

Amino Acids, Acidic/chemical synthesis; Amino Acids, Acidic/pharmacokinetics; Receptors, Glutamate/metabolism; Alanine; Bridged Bicyclo Compounds/chemical synthesis; Glycine; Humans; Ligands; Pentanes/chemical synthesis; Protein Binding; Receptors, N-Methyl-D-Aspartate/agonists; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Glutamate / Amino Acids, Acidic Limits: Humans Language: En Journal: Bioorg Med Chem Year: 2009 Document type: Article

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