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Expression of the osmotically responsive cationic channel TRPV4 in the endolymphatic sac.
Kumagami, H; Terakado, M; Sainoo, Y; Baba, A; Fujiyama, D; Fukuda, T; Takasaki, K; Takahashi, H.
Affiliation
  • Kumagami H; Department of Otolaryngology, Nagasaki University, Sakamoto 1-7-1, Nagasaki 852-8501, Japan. kumagami@nagasaki-u.ac.jp
Audiol Neurootol ; 14(3): 190-7, 2009.
Article in En | MEDLINE | ID: mdl-19066426
ABSTRACT
The immunohistochemical expression pattern and the physiological role of transient receptor potential vanilloid (TRPV) 4 in the endolymphatic sac were investigated. TRPV4 was expressed predominantly in the apical membrane of mitochondria-rich cells, and cell volume regulation by TRPV4 was observed in a tissue culture of the rat endolymphatic sac. TRPV4 was also present in the endolymphatic sacs of patients with vestibular schwannoma and with Ménière's disease. TRPV4 is assumed to play a role as an osmoreceptor in cell and fluid volume regulation in the human endolymphatic sac.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endolymphatic Sac / Neuroma, Acoustic / TRPV Cation Channels Limits: Adult / Animals / Humans / Middle aged Language: En Journal: Audiol Neurootol Year: 2009 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endolymphatic Sac / Neuroma, Acoustic / TRPV Cation Channels Limits: Adult / Animals / Humans / Middle aged Language: En Journal: Audiol Neurootol Year: 2009 Document type: Article