Expression of the osmotically responsive cationic channel TRPV4 in the endolymphatic sac.
Audiol Neurootol
; 14(3): 190-7, 2009.
Article
in En
| MEDLINE
| ID: mdl-19066426
ABSTRACT
The immunohistochemical expression pattern and the physiological role of transient receptor potential vanilloid (TRPV) 4 in the endolymphatic sac were investigated. TRPV4 was expressed predominantly in the apical membrane of mitochondria-rich cells, and cell volume regulation by TRPV4 was observed in a tissue culture of the rat endolymphatic sac. TRPV4 was also present in the endolymphatic sacs of patients with vestibular schwannoma and with Ménière's disease. TRPV4 is assumed to play a role as an osmoreceptor in cell and fluid volume regulation in the human endolymphatic sac.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endolymphatic Sac
/
Neuroma, Acoustic
/
TRPV Cation Channels
Limits:
Adult
/
Animals
/
Humans
/
Middle aged
Language:
En
Journal:
Audiol Neurootol
Year:
2009
Document type:
Article