Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis.

Zraika, S; Hull, R L; Udayasankar, J; Aston-Mourney, K; Subramanian, S L; Kisilevsky, R; Szarek, W A; Kahn, S E

Zraika, S; Hull, R L; Udayasankar, J; Aston-Mourney, K; Subramanian, S L; Kisilevsky, R; Szarek, W A; Kahn, S E.

Affiliation

Zraika S; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington and VA Puget Sound Health Care System, 1660 South Columbian Way (151), Seattle, WA 98108, USA. zraikas@u.washington.edu

Diabetologia ; 52(4): 626-35, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19148619

Subject(s)

Amyloid/biosynthesis; Apoptosis/physiology; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/physiology; Oxidative Stress/physiology; Amyloid/genetics; Amyloid/physiology; Animals; Diabetes Mellitus, Type 2/physiopathology; Humans; Insulin/genetics; Insulin/metabolism; Insulin Secretion; Insulin-Secreting Cells/metabolism; Islet Amyloid Polypeptide; Mice; Mice, Transgenic; RNA, Messenger/genetics; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Apoptosis / Oxidative Stress / Insulin-Secreting Cells / Amyloid Limits: Animals / Humans Language: En Journal: Diabetologia Year: 2009 Document type: Article

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