Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways.

Chiu, Hui-Wen; Ho, Sheng-Yow; Guo, How-Ran; Wang, Ying-Jan

Chiu, Hui-Wen; Ho, Sheng-Yow; Guo, How-Ran; Wang, Ying-Jan.

Affiliation

Chiu HW; Department of Environmental and Occupational Health, National Cheng Kung University, Medical College, 138 Sheng-Li Road, Tainan, Taiwan.

Autophagy ; 5(4): 472-83, 2009 May.

Article in En | MEDLINE | ID: mdl-19242099

Subject(s)

Arsenicals/pharmacology; Autophagy/drug effects; Autophagy/radiation effects; Extracellular Signal-Regulated MAP Kinases/metabolism; MAP Kinase Signaling System/drug effects; Oxides/pharmacology; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Acridine Orange; Apoptosis/drug effects; Apoptosis/radiation effects; Arsenic Trioxide; Cell Line, Tumor; Combined Modality Therapy; Cytoplasmic Vesicles/drug effects; Cytoplasmic Vesicles/radiation effects; Cytoplasmic Vesicles/ultrastructure; Dose-Response Relationship, Radiation; Humans; MAP Kinase Signaling System/radiation effects; Membrane Potential, Mitochondrial/drug effects; Membrane Potential, Mitochondrial/radiation effects; Microscopy, Fluorescence; Microtubule-Associated Proteins/metabolism; Mitosis/drug effects; Mitosis/radiation effects; Mitotic Index; Radiation, Ionizing; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Oxides / Arsenicals / Autophagy / Phosphatidylinositol 3-Kinases / MAP Kinase Signaling System / Extracellular Signal-Regulated MAP Kinases / Proto-Oncogene Proteins c-akt Limits: Humans Language: En Journal: Autophagy Year: 2009 Document type: Article

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