Heterologous stacking of prion protein peptides reveals structural details of fibrils and facilitates complete inhibition of fibril growth.

Boshuizen, Ronald S; Schulz, Veronica; Morbin, Michela; Mazzoleni, Giulia; Meloen, Rob H; Langedijk, Johannes P M

Boshuizen, Ronald S; Schulz, Veronica; Morbin, Michela; Mazzoleni, Giulia; Meloen, Rob H; Langedijk, Johannes P M.

Affiliation

Boshuizen RS; Pepscan Therapeutics BV, Zuidersluisweg 2, Lelystad, The Netherlands. r.boshuizen@pepscan.com

J Biol Chem ; 284(19): 12809-20, 2009 May 08.

Article in En | MEDLINE | ID: mdl-19304665

Subject(s)

Peptide Fragments/chemistry; PrPSc Proteins/chemistry; Amino Acid Sequence; Chromatography, High Pressure Liquid; Cyclization; Dimerization; Humans; Models, Molecular; Molecular Mimicry; Molecular Sequence Data; Nucleotidyltransferases/chemistry; Nucleotidyltransferases/metabolism; Peptide Fragments/metabolism; PrPSc Proteins/antagonists & inhibitors; PrPSc Proteins/metabolism; Protein Conformation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / PrPSc Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2009 Document type: Article

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