Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes.

Arndt, T; Wedekind, D; Weiss, H; Tiedge, M; Lenzen, S; Hedrich, H-J; Jörns, A

Arndt, T; Wedekind, D; Weiss, H; Tiedge, M; Lenzen, S; Hedrich, H-J; Jörns, A.

Affiliation

Arndt T; Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.

Diabetologia ; 52(7): 1381-90, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19367386

Subject(s)

Adoptive Transfer/methods; CD8-Positive T-Lymphocytes/transplantation; Diabetes Mellitus, Type 1/prevention & control; Lymph Nodes/immunology; Pancreas/immunology; Prediabetic State/therapy; Animals; Blood Glucose; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/transplantation; CD8-Positive T-Lymphocytes/immunology; Cytokines/genetics; Cytokines/immunology; Diabetes Mellitus, Type 1/immunology; Disease Models, Animal; Gene Expression/immunology; Immunophenotyping; Prediabetic State/immunology; Rats; Rats, Inbred Lew; Rats, Nude; T-Lymphocytes, Regulatory/cytology; T-Lymphocytes, Regulatory/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreas / Prediabetic State / CD8-Positive T-Lymphocytes / Adoptive Transfer / Diabetes Mellitus, Type 1 / Lymph Nodes Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Diabetologia Year: 2009 Document type: Article

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