A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

Serenó, L; Coma, M; Rodríguez, M; Sánchez-Ferrer, P; Sánchez, M B; Gich, I; Agulló, J M; Pérez, M; Avila, J; Guardia-Laguarta, C; Clarimón, J; Lleó, A; Gómez-Isla, T

Serenó, L; Coma, M; Rodríguez, M; Sánchez-Ferrer, P; Sánchez, M B; Gich, I; Agulló, J M; Pérez, M; Avila, J; Guardia-Laguarta, C; Clarimón, J; Lleó, A; Gómez-Isla, T.

Affiliation

Serenó L; Departamento de Neurología, Hospital Santa Cruz y San Pablo, Universidad Autónoma de Barcelona, Barcelona, Spain.

Neurobiol Dis ; 35(3): 359-67, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19523516

Subject(s)

Alzheimer Disease/drug therapy; Alzheimer Disease/pathology; Enzyme Inhibitors/pharmacology; Neurons/drug effects; Neurons/pathology; Thiadiazoles/pharmacology; Amyloid/metabolism; Amyloid beta-Protein Precursor/genetics; Animals; Astrocytes/drug effects; Astrocytes/pathology; Astrocytes/physiology; Cell Death/drug effects; Entorhinal Cortex/drug effects; Entorhinal Cortex/pathology; Enzyme Inhibitors/blood; Female; Glycogen Synthase Kinase 3/antagonists & inhibitors; Glycogen Synthase Kinase 3 beta; Hippocampus/drug effects; Hippocampus/pathology; Humans; Male; Memory/drug effects; Memory Disorders/drug therapy; Memory Disorders/pathology; Mice; Mice, Transgenic; Protease Nexins; Receptors, Cell Surface/genetics; Space Perception/drug effects; Thiadiazoles/blood; tau Proteins/genetics

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Thiadiazoles / Enzyme Inhibitors / Alzheimer Disease / Neurons Limits: Animals / Female / Humans / Male Language: En Journal: Neurobiol Dis Year: 2009 Document type: Article

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