Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome.

Al Khatib, Shadi; Keles, Sevgi; Garcia-Lloret, Maria; Karakoc-Aydiner, Elif; Reisli, Ismail; Artac, Hasibe; Camcioglu, Yildiz; Cokugras, Haluk; Somer, Ayper; Kutukculer, Necil; Yilmaz, Mustafa; Ikinciogullari, Aydan; Yegin, Olcay; Yüksek, Mutlu; Genel, Ferah; Kucukosmanoglu, Ercan; Baki, Ali; Bahceciler, Nerin N; Rambhatla, Anupama; Nickerson, Derek W; McGhee, Sean; Barlan, Isil B; Chatila, Talal

Al Khatib, Shadi; Keles, Sevgi; Garcia-Lloret, Maria; Karakoc-Aydiner, Elif; Reisli, Ismail; Artac, Hasibe; Camcioglu, Yildiz; Cokugras, Haluk; Somer, Ayper; Kutukculer, Necil; Yilmaz, Mustafa; Ikinciogullari, Aydan; Yegin, Olcay; Yüksek, Mutlu; Genel, Ferah; Kucukosmanoglu, Ercan; Baki, Ali; Bahceciler, Nerin N; Rambhatla, Anupama; Nickerson, Derek W; McGhee, Sean; Barlan, Isil B; Chatila, Talal.

Affiliation

Al Khatib S; Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, Calif 90095-1752, USA.

J Allergy Clin Immunol ; 124(2): 342-8, 348.e1-5, 2009 Aug.

Article in En | MEDLINE | ID: mdl-19577286

Subject(s)

Cell Differentiation/immunology; Interleukin-17/immunology; Job Syndrome/genetics; STAT3 Transcription Factor/genetics; T-Lymphocytes, Helper-Inducer/immunology; Adolescent; Cell Differentiation/drug effects; Cell Differentiation/genetics; Child; Child, Preschool; Cohort Studies; Female; Humans; Immunoglobulin E/blood; Infant; Interferon-alpha/pharmacology; Interferon-gamma/biosynthesis; Interferon-gamma/immunology; Interleukin-1/pharmacology; Interleukin-12/pharmacology; Interleukin-23/pharmacology; Interleukin-6/pharmacology; Interleukins/pharmacology; Job Syndrome/immunology; Male; Mutation/genetics; Nuclear Receptor Subfamily 1, Group F, Member 3; Phosphorylation/drug effects; Phosphorylation/immunology; Receptors, Retinoic Acid/immunology; Receptors, Retinoic Acid/metabolism; Receptors, Thyroid Hormone/immunology; Receptors, Thyroid Hormone/metabolism; STAT1 Transcription Factor/genetics; STAT1 Transcription Factor/metabolism; STAT3 Transcription Factor/metabolism; T-Lymphocytes, Helper-Inducer/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / T-Lymphocytes, Helper-Inducer / Interleukin-17 / STAT3 Transcription Factor / Job Syndrome Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Language: En Journal: J Allergy Clin Immunol Year: 2009 Document type: Article

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