Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans.

Monroy, A; Kamath, S; Chavez, A O; Centonze, V E; Veerasamy, M; Barrentine, A; Wewer, J J; Coletta, D K; Jenkinson, C; Jhingan, R M; Smokler, D; Reyna, S; Musi, N; Khokka, R; Federici, M; Tripathy, D; DeFronzo, R A; Folli, F

Monroy, A; Kamath, S; Chavez, A O; Centonze, V E; Veerasamy, M; Barrentine, A; Wewer, J J; Coletta, D K; Jenkinson, C; Jhingan, R M; Smokler, D; Reyna, S; Musi, N; Khokka, R; Federici, M; Tripathy, D; DeFronzo, R A; Folli, F.

Affiliation

Monroy A; Department of Medicine, University of Texas Health Science Center at San Antonio, 78229-3900, USA.

Diabetologia ; 52(10): 2169-81, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19633828

Subject(s)

ADAM Proteins/metabolism; Diabetes Mellitus, Type 2/metabolism; Gene Expression Regulation; Insulin Resistance/physiology; Muscle, Skeletal/metabolism; Tissue Inhibitor of Metalloproteinase-3/metabolism; ADAM Proteins/genetics; ADAM17 Protein; Adult; Blotting, Western; Diabetes Mellitus, Type 2/genetics; Enzyme-Linked Immunosorbent Assay; Female; Humans; Insulin Resistance/genetics; Male; Receptors, Interleukin-6/genetics; Receptors, Interleukin-6/metabolism; Tissue Inhibitor of Metalloproteinase-3/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Gene Expression Regulation / Muscle, Skeletal / Tissue Inhibitor of Metalloproteinase-3 / Diabetes Mellitus, Type 2 / ADAM Proteins Limits: Adult / Female / Humans / Male Language: En Journal: Diabetologia Year: 2009 Document type: Article

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