Discovery of a new template for anticancer agents: 2'-deoxy-2'-fluoro-4'-selenoarabinofuranosyl-cytosine (2'-F-4'-seleno-ara-C).

Jeong, Lak Shin; Tosh, Dilip K; Choi, Won Jun; Lee, Sang Kook; Kang, You-Jin; Choi, Sun; Lee, Jin Hee; Lee, Hankil; Lee, Hyuk Woo; Kim, Hea Ok

Jeong, Lak Shin; Tosh, Dilip K; Choi, Won Jun; Lee, Sang Kook; Kang, You-Jin; Choi, Sun; Lee, Jin Hee; Lee, Hankil; Lee, Hyuk Woo; Kim, Hea Ok.

Affiliation

Jeong LS; Department of Bioinspired Science, Division of Life and Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr

J Med Chem ; 52(17): 5303-6, 2009 Sep 10.

Article in En | MEDLINE | ID: mdl-19691349

Subject(s)

Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Cytarabine/analogs & derivatives; Cytosine/chemical synthesis; Cytosine/pharmacology; Organoselenium Compounds/chemical synthesis; Organoselenium Compounds/pharmacology; Antineoplastic Agents/chemistry; Cell Line, Tumor; Cytarabine/chemical synthesis; Cytarabine/chemistry; Cytarabine/pharmacology; Cytosine/chemistry; Drug Discovery; Halogenation; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Organoselenium Compounds/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoselenium Compounds / Cytarabine / Cytosine / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Year: 2009 Document type: Article

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