p53 ancestry: gazing through an evolutionary lens.
Nat Rev Cancer
; 9(10): 758-62, 2009 10.
Article
in En
| MEDLINE
| ID: mdl-19776745
Evolutionary patterns indicate that primordial p53 genes predated the appearance of cancer. Therefore, wild-type tumour suppressive functions and mutant oncogenic functions that give celebrity status to this gene family were probably co-opted from unrelated primordial activities. Is it possible to deduce what these early functions might have been? And might this knowledge provide a platform for therapeutic opportunities?
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genes, p53
/
Tumor Suppressor Protein p53
/
Evolution, Molecular
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Rev Cancer
Year:
2009
Document type:
Article