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p53 ancestry: gazing through an evolutionary lens.
Lu, Wan-Jin; Amatruda, James F; Abrams, John M.
Affiliation
  • Lu WJ; Wan-Jin Lu and John M. Abrams are at the Department of Cell Biology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA.
Nat Rev Cancer ; 9(10): 758-62, 2009 10.
Article in En | MEDLINE | ID: mdl-19776745
Evolutionary patterns indicate that primordial p53 genes predated the appearance of cancer. Therefore, wild-type tumour suppressive functions and mutant oncogenic functions that give celebrity status to this gene family were probably co-opted from unrelated primordial activities. Is it possible to deduce what these early functions might have been? And might this knowledge provide a platform for therapeutic opportunities?
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genes, p53 / Tumor Suppressor Protein p53 / Evolution, Molecular Limits: Animals / Humans Language: En Journal: Nat Rev Cancer Year: 2009 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genes, p53 / Tumor Suppressor Protein p53 / Evolution, Molecular Limits: Animals / Humans Language: En Journal: Nat Rev Cancer Year: 2009 Document type: Article