Possible neuroprotective effect of brimonidine in a mouse model of ischaemic optic neuropathy.

Goldenberg-Cohen, Nitza; Dadon-Bar-El, Shimrit; Hasanreisoglu, Murat; Avraham-Lubin, Bat Chen R; Dratviman-Storobinsky, Olga; Cohen, Yoram; Weinberger, Dov

Goldenberg-Cohen, Nitza; Dadon-Bar-El, Shimrit; Hasanreisoglu, Murat; Avraham-Lubin, Bat Chen R; Dratviman-Storobinsky, Olga; Cohen, Yoram; Weinberger, Dov.

Affiliation

Goldenberg-Cohen N; Pediatric Division of Ophthalmology, Schneider Children's Medical Center of Israel, Tel Aviv, Israel.

Clin Exp Ophthalmol ; 37(7): 718-29, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19788670

Subject(s)

Disease Models, Animal; Neuroprotective Agents/therapeutic use; Optic Neuropathy, Ischemic/prevention & control; Quinoxalines/therapeutic use; Animals; Brimonidine Tartrate; Eye Proteins/genetics; Fluorescent Antibody Technique, Indirect; Gene Expression; Glutathione Peroxidase/genetics; Heme Oxygenase-1/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factors/genetics; Nitric Oxide Synthase Type III/genetics; Optic Neuropathy, Ischemic/genetics; Optic Neuropathy, Ischemic/pathology; Oxidative Stress/genetics; Receptor Protein-Tyrosine Kinases/genetics; Receptor, TIE-2; Retinal Ganglion Cells/pathology; Retinal Neovascularization/genetics; Serpins/genetics; Superoxide Dismutase/genetics; Superoxide Dismutase-1; Vascular Endothelial Growth Factor A/genetics; Glutathione Peroxidase GPX1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinoxalines / Neuroprotective Agents / Optic Neuropathy, Ischemic / Disease Models, Animal Type of study: Prognostic_studies Limits: Animals Language: En Journal: Clin Exp Ophthalmol Year: 2009 Document type: Article

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