[Leishmaniases in France: an update]. / Actualités sur les leishmanioses en France.
Arch Pediatr
; 16 Suppl 2: S96-100, 2009 Oct.
Article
in Fr
| MEDLINE
| ID: mdl-19836685
ABSTRACT
Leishmaniases are parasitic diseases due to a flagellate protozoan of the genus Leishmania. They are transmitted from mammal to mammal by the bite of an arthropod vector a female sandfly. Among the different clinical presentations, the zoonotic visceral leishmaniasis (ZVL) is due to Leishmania infantum. Dogs are the reservoir and can develop a deadly disease. ZVL is described in China, Pakistan, Latin America and in the Mediterranean region, particularly in the South of France. In recent years, many asymptomatic carriers have been described. Despite the fact that cases in immunocompromised adults are the majority, the classic Mediterranean ZVL in young children is still observed. The classic triad of symptoms is fever, pallor, splenomegaly and hepatomegaly in half of the cases. The biological orientation is a low blood count (anemia, leuconeutropenia, and thrombocytopenia) and an inflammatory syndrome. Serological tests are useful, but the diagnosis is made by the identification of the parasite in a bone marrow sample. Today, the treatment is done by the liposomal amphotericin B (AmBisome) and the total dose must to be 20 mg/kg.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leishmaniasis
/
Amphotericin B
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limits:
Animals
/
Child
/
Female
/
Humans
Language:
Fr
Journal:
Arch Pediatr
Year:
2009
Document type:
Article