Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma.

Bhavsar, P; Khorasani, N; Hew, M; Johnson, M; Chung, K F

Bhavsar, P; Khorasani, N; Hew, M; Johnson, M; Chung, K F.

Affiliation

Bhavsar P; Section of Airways Disease, National Heart & Lung Institute, Imperial College & Royal Brompton and Harefield NHS Trust Hospital, London, UK.

Eur Respir J ; 35(4): 750-6, 2010 Apr.

Article in En | MEDLINE | ID: mdl-19840967

Subject(s)

Adrenal Cortex Hormones/pharmacology; Asthma; Cytokines/metabolism; Dexamethasone/pharmacology; Macrophages, Alveolar; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; Adult; Asthma/drug therapy; Asthma/immunology; Asthma/metabolism; Cells, Cultured; Chemokine CCL3/metabolism; Drug Synergism; Enzyme Inhibitors/pharmacology; Female; Humans; Indoles/pharmacology; Interleukin-10/metabolism; Interleukin-1beta/metabolism; Interleukin-6/metabolism; Lipopolysaccharides/pharmacology; Macrophages, Alveolar/drug effects; Macrophages, Alveolar/enzymology; Macrophages, Alveolar/immunology; Male; Middle Aged; Phosphorylation/drug effects; Severity of Illness Index; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Dexamethasone / Cytokines / Macrophages, Alveolar / Adrenal Cortex Hormones / P38 Mitogen-Activated Protein Kinases Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Eur Respir J Year: 2010 Document type: Article

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