Separate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: comparison with the profile in non-cannulated mice.

Kuze, J; Mutoh, T; Takenaka, T; Morisaki, K; Nakura, H; Hanioka, N; Narimatsu, S

Kuze, J; Mutoh, T; Takenaka, T; Morisaki, K; Nakura, H; Hanioka, N; Narimatsu, S.

Affiliation

Kuze J; Evaluation Research Laboratory, Hanno Research Center, Taiho Pharmaceutical Co., Ltd, Saitama, Japan.

Xenobiotica ; 39(11): 871-80, 2009 Nov.

Article in En | MEDLINE | ID: mdl-19845438

Subject(s)

Alprazolam/pharmacokinetics; Benzodiazepines/pharmacokinetics; Intestinal Mucosa/metabolism; Liver/metabolism; Midazolam/pharmacokinetics; Triazolam/pharmacokinetics; Administration, Oral; Alprazolam/administration & dosage; Alprazolam/chemistry; Animals; Benzodiazepines/chemistry; Biological Availability; Catheterization; Jugular Veins; Male; Mice; Mice, Inbred BALB C; Midazolam/administration & dosage; Midazolam/chemistry; Portal Vein; Rats; Rats, Sprague-Dawley; Triazolam/administration & dosage; Triazolam/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazolam / Benzodiazepines / Alprazolam / Midazolam / Intestinal Mucosa / Liver Limits: Animals Language: En Journal: Xenobiotica Year: 2009 Document type: Article

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