Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys.
Diabetologia
; 53(1): 111-4, 2010 Jan.
Article
in En
| MEDLINE
| ID: mdl-19847395
ABSTRACT
AIMS/HYPOTHESIS:
We sought to establish the relationship between fasting plasma glucose concentrations and pancreatic fractional beta cell area in adult cynomolgus monkeys (Macaca fascicularis).METHODS:
Fasting plasma glucose and pancreatic fractional beta cell area were measured in 18 control and 17 streptozotocin-treated adult primates (17.0 +/- 1.2 vs 15.4 +/- 1.2 years old).RESULTS:
Fasting plasma glucose was increased (12.0 +/- 2.0 vs 3.4 +/- 0.1 mmol/l, p < 0.01) and fractional beta cell area was decreased (0.62 +/- 0.13% vs 2.49 +/- 0.35%, p < 0.01) in streptozotocin-treated monkeys. The relationship between fasting plasma glucose and pancreatic fractional beta cell area was described by a wide range of beta cell areas in controls. In streptozotocin-treated monkeys there was an inflection of fasting blood glucose at approximately 50% of the mean beta cell area in controls with a steep increase in blood glucose for each further decrement in beta cell area. CONCLUSIONS/INTERPRETATION:
In adult non-human primates a decrement in fractional beta cell area of approximately 50% or more leads to loss of glycaemic control.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Glucose
/
Insulin-Secreting Cells
/
Hyperglycemia
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Diabetologia
Year:
2010
Document type:
Article