Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats.

Chen, Guo Qian; Chen, Yan Yan; Wang, Xin Shi; Wu, Sai Zhen; Yang, Hui Min; Xu, Hui Qin; He, Jin Cai; Wang, Xiao Tong; Chen, Jiang Fan; Zheng, Rong Yuan

Chen, Guo Qian; Chen, Yan Yan; Wang, Xin Shi; Wu, Sai Zhen; Yang, Hui Min; Xu, Hui Qin; He, Jin Cai; Wang, Xiao Tong; Chen, Jiang Fan; Zheng, Rong Yuan.

Affiliation

Chen GQ; Department of Neurology, the First Affiliated Hospital and Research Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, Zhejiang, PR China.

Brain Res ; 1309: 116-25, 2010 Jan 14.

Article in En | MEDLINE | ID: mdl-19879252

Subject(s)

Caffeine/pharmacology; Central Nervous System/drug effects; Encephalomyelitis, Autoimmune, Experimental/drug therapy; Animals; Caffeine/therapeutic use; Central Nervous System/immunology; Central Nervous System/physiopathology; Cytokines/metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation/drug effects; Down-Regulation/genetics; Drug Administration Schedule; Encephalomyelitis, Autoimmune, Experimental/immunology; Encephalomyelitis, Autoimmune, Experimental/physiopathology; Guinea Pigs; Interferon-gamma/metabolism; Multiple Sclerosis/drug therapy; Multiple Sclerosis/immunology; Multiple Sclerosis/physiopathology; RNA, Messenger/drug effects; RNA, Messenger/metabolism; Rats; Rats, Wistar; Receptor, Adenosine A1/genetics; Receptor, Adenosine A2A/genetics; Spinal Cord/chemistry; Spinal Cord/immunology; Subcellular Fractions; Th1 Cells/drug effects; Th1 Cells/immunology; Th1 Cells/metabolism; Th2 Cells/drug effects; Th2 Cells/immunology; Th2 Cells/metabolism; Transforming Growth Factor beta/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caffeine / Central Nervous System / Encephalomyelitis, Autoimmune, Experimental Type of study: Prognostic_studies Language: En Journal: Brain Res Year: 2010 Document type: Article

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