C3aR inhibition reduces neurodegeneration in experimental lupus.

Jacob, A; Bao, L; Brorson, J; Quigg, R J; Alexander, J J

Jacob, A; Bao, L; Brorson, J; Quigg, R J; Alexander, J J.

Affiliation

Jacob A; Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

Lupus ; 19(1): 73-82, 2010 Jan.

Article in En | MEDLINE | ID: mdl-19900981

Subject(s)

Lupus Erythematosus, Systemic/complications; Neurodegenerative Diseases/etiology; Receptors, Complement/physiology; Animals; Apoptosis; Complement Activation; Gliosis/prevention & control; Interferon-gamma/physiology; Lupus Erythematosus, Systemic/immunology; Male; Mice; Mice, Inbred MRL lpr; Neurodegenerative Diseases/prevention & control; Neurons/pathology; Nitric Oxide Synthase Type II/genetics; Receptors, AMPA/physiology; Receptors, Complement/antagonists & inhibitors; Signal Transduction

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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Receptors, Complement / Neurodegenerative Diseases / Lupus Erythematosus, Systemic Type of study: Prognostic_studies Limits: Animals Language: En Journal: Lupus Year: 2010 Document type: Article

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