CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression.

Raison, C L; Dantzer, R; Kelley, K W; Lawson, M A; Woolwine, B J; Vogt, G; Spivey, J R; Saito, K; Miller, A H

Raison, C L; Dantzer, R; Kelley, K W; Lawson, M A; Woolwine, B J; Vogt, G; Spivey, J R; Saito, K; Miller, A H.

Affiliation

Raison CL; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.

Mol Psychiatry ; 15(4): 393-403, 2010 Apr.

Article in En | MEDLINE | ID: mdl-19918244

Subject(s)

Depression/etiology; Hepatitis C; Interferon-alpha/therapeutic use; Kynurenine/cerebrospinal fluid; Tryptophan/cerebrospinal fluid; Adult; Antiviral Agents/therapeutic use; Chemokine CCL2/cerebrospinal fluid; Chromatography, High Pressure Liquid/methods; Cytokines/cerebrospinal fluid; Depression/cerebrospinal fluid; Enzyme-Linked Immunosorbent Assay/methods; Female; Hepatitis C/blood; Hepatitis C/cerebrospinal fluid; Hepatitis C/complications; Hepatitis C/immunology; Humans; Kynurenine/blood; Longitudinal Studies; Male; Middle Aged; Quinolinic Acid/blood; Quinolinic Acid/cerebrospinal fluid; Receptors, Tumor Necrosis Factor, Type II/cerebrospinal fluid; Ribavirin/therapeutic use; Statistics as Topic; Tryptophan/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan / Interferon-alpha / Hepatitis C / Depression / Kynurenine Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Mol Psychiatry Year: 2010 Document type: Article

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