Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease.

Coma, M; Serenó, L; Da Rocha-Souto, B; Scotton, T C; España, J; Sánchez, M B; Rodríguez, M; Agulló, J; Guardia-Laguarta, C; Garcia-Alloza, M; Borrelli, L A; Clarimón, J; Lleó, A; Bacskai, B J; Saura, C A; Hyman, B T; Gómez-Isla, T

Coma, M; Serenó, L; Da Rocha-Souto, B; Scotton, T C; España, J; Sánchez, M B; Rodríguez, M; Agulló, J; Guardia-Laguarta, C; Garcia-Alloza, M; Borrelli, L A; Clarimón, J; Lleó, A; Bacskai, B J; Saura, C A; Hyman, B T; Gómez-Isla, T.

Affiliation

Coma M; Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Neurobiol Dis ; 38(3): 482-91, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20149872

Subject(s)

Alzheimer Disease/drug therapy; Alzheimer Disease/metabolism; Brain/drug effects; Brain/metabolism; Central Nervous System Agents/pharmacology; Salicylates/pharmacology; Alzheimer Disease/pathology; Amyloid beta-Peptides/genetics; Amyloid beta-Peptides/metabolism; Animals; Axons/drug effects; Axons/pathology; Brain/pathology; Brain-Derived Neurotrophic Factor/metabolism; Cognition Disorders/drug therapy; Cognition Disorders/metabolism; Cognition Disorders/pathology; Cytokines/metabolism; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia/drug effects; Neuroglia/pathology; Plaque, Amyloid/drug effects; Plaque, Amyloid/metabolism; Plaque, Amyloid/pathology; Proto-Oncogene Proteins c-fos/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Central Nervous System Agents / Salicylates / Alzheimer Disease Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Neurobiol Dis Year: 2010 Document type: Article

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