Corticosteroid insensitivity in severe asthma: significance, mechanisms and aetiology.
Intern Med J
; 40(5): 323-34, 2010 May.
Article
in En
| MEDLINE
| ID: mdl-20180872
ABSTRACT
Chronic severe asthma remains a challenging clinical problem despite the availability of modern treatments. Relative corticosteroid insensitivity is present in severe asthma and may contribute to continuing disease severity. Advances in the understanding of molecular mechanisms underlying corticosteroid insensitivity may yield new therapeutic targets. Furthermore, aetiological factors for corticosteroid insensitivity have been identified and these may be amenable to modification.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Drug Resistance
/
Adrenal Cortex Hormones
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Intern Med J
Year:
2010
Document type:
Article