Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells.

Luo, P; Yang, X; Ying, M; Chaudhry, P; Wang, A; Shimada, H; May, W A; Adams, G B; Mock, D; Triche, T J; He, Q; Wu, L

Luo, P; Yang, X; Ying, M; Chaudhry, P; Wang, A; Shimada, H; May, W A; Adams, G B; Mock, D; Triche, T J; He, Q; Wu, L.

Affiliation

Luo P; Department of Pathology, Childrens Hospital Los Angeles Saban Research Institute, Los Angeles, CA 90027, USA.

Oncogene ; 29(19): 2772-83, 2010 May 13.

Article in En | MEDLINE | ID: mdl-20190807

Subject(s)

Cell Differentiation/drug effects; Osteosarcoma/pathology; Receptors, Retinoic Acid/metabolism; Signal Transduction/drug effects; Tretinoin/pharmacology; Animals; Cell Line, Tumor; Cell Proliferation/drug effects; Cyclin-Dependent Kinases/metabolism; Fibroblast Growth Factor 8/genetics; G1 Phase/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Humans; Mice; Mice, Inbred BALB C; Mutation; Osteoblasts/drug effects; Osteoblasts/pathology; Osteosarcoma/genetics; Osteosarcoma/metabolism; Phosphorylation/drug effects; Receptors, Retinoic Acid/genetics; Retinoic Acid Receptor alpha; Cyclin-Dependent Kinase-Activating Kinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tretinoin / Signal Transduction / Osteosarcoma / Cell Differentiation / Receptors, Retinoic Acid Limits: Animals / Humans Language: En Journal: Oncogene Year: 2010 Document type: Article

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