Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients.
Physiol Res
; 59(5): 749-755, 2010.
Article
in En
| MEDLINE
| ID: mdl-20406045
ABSTRACT
Glucose-dependent insulinotropic peptide (GIP) contributes to incretin effect of insulin secretion which is impaired in Type 2 diabetes mellitus. The aim of this study was to introduce a simple meal test for evaluation of GIP secretion and action and to examine GIP changes in Type 2 diabetic patients. Seventeen Type 2 diabetic patients, 10 obese non-diabetic and 17 non-obese control persons have been examined before and after 30, 60 and 90 min stimulation by meal test. Serum concentrations of insulin, C-peptide and GIP were estimated during the test. Impaired GIP secretion was found in Type 2 diabetic patients as compared with obese non-diabetic and non-obese control persons. The AUCGIP during 90 min of the meal stimulation was significantly lower in diabetic patients than in other two groups (p<0.03). Insulin concentration at 30 min was lower in diabetic than in non-diabetic persons and the GIP action was delayed. The deltaIRI/deltaGIP ratio increased during the test in diabetic patients, whereas it progressively decreased in obese and non-obese control persons. Simple meal test could demonstrate impaired GIP secretion and delayed insulin secretion in Type 2 diabetic patients as compared to obese non-diabetic and non-obese healthy control individuals.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gastric Inhibitory Polypeptide
/
Diabetes Mellitus, Type 2
/
Diagnostic Techniques, Endocrine
/
Obesity
Type of study:
Diagnostic_studies
Limits:
Adult
/
Aged
/
Humans
/
Middle aged
Language:
En
Journal:
Physiol Res
Year:
2010
Document type:
Article