Fukinolic acid derivatives and triterpene glycosides from black cohosh inhibit CYP isozymes, but are not cytotoxic to Hep-G2 cells in vitro.

Huang, Yue; Jiang, Bei; Nuntanakorn, Paiboon; Kennelly, Edward J; Shord, Stacy; Lawal, Temitope O; Mahady, G B

Huang, Yue; Jiang, Bei; Nuntanakorn, Paiboon; Kennelly, Edward J; Shord, Stacy; Lawal, Temitope O; Mahady, G B.

Affiliation

Huang Y; Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St, Chicago, IL 60612, USA.

Curr Drug Saf ; 5(2): 118-24, 2010 Apr.

Article in En | MEDLINE | ID: mdl-20406160

Subject(s)

Caffeic Acids/pharmacology; Cimicifuga; Cytochrome P-450 Enzyme Inhibitors; Cytotoxins/pharmacology; Glycosides/pharmacology; Phenylacetates/pharmacology; Triterpenes/pharmacology; Caffeic Acids/chemistry; Caffeic Acids/isolation & purification; Cytochrome P-450 Enzyme System/metabolism; Cytotoxins/chemistry; Cytotoxins/isolation & purification; Female; Glycosides/chemistry; Glycosides/isolation & purification; Hep G2 Cells; Humans; Isoenzymes/antagonists & inhibitors; Isoenzymes/metabolism; Liver/drug effects; Liver/enzymology; Liver/pathology; Menopause/drug effects; Menopause/metabolism; Phenylacetates/chemistry; Phenylacetates/isolation & purification; Plant Extracts/chemistry; Plant Extracts/isolation & purification; Plant Extracts/pharmacology; Plant Roots; Rhizome; Triterpenes/chemistry; Triterpenes/isolation & purification

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylacetates / Triterpenes / Caffeic Acids / Cytotoxins / Cimicifuga / Cytochrome P-450 Enzyme Inhibitors / Glycosides Limits: Female / Humans Language: En Journal: Curr Drug Saf Year: 2010 Document type: Article

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