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Common variants in FOXP1 are associated with generalized vitiligo.
Jin, Ying; Birlea, Stanca A; Fain, Pamela R; Mailloux, Christina M; Riccardi, Sheri L; Gowan, Katherine; Holland, Paulene J; Bennett, Dorothy C; Wallace, Margaret R; McCormack, Wayne T; Kemp, E Helen; Gawkrodger, David J; Weetman, Anthony P; Picardo, Mauro; Leone, Giovanni; Taïeb, Alain; Jouary, Thomas; Ezzedine, Khaled; van Geel, Nanny; Lambert, Jo; Overbeck, Andreas; Spritz, Richard A.
Affiliation
  • Jin Y; Human Medical Genetics Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Nat Genet ; 42(7): 576-8, 2010 Jul.
Article in En | MEDLINE | ID: mdl-20526340
ABSTRACT
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P=1.04x10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P=3.94x10(-7)).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Vitiligo / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Forkhead Transcription Factors Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Genet Year: 2010 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Vitiligo / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Forkhead Transcription Factors Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Genet Year: 2010 Document type: Article