Synthesis and transdermal permeation of novel N4-methoxypoly(ethylene glycol) carbamates of cytarabine.

Legoabe, Lesetja J; N'Da, David D; Breytenbach, Jaco C; du Preez, Jan L; du Plessis, Jeanetta

Legoabe, Lesetja J; N'Da, David D; Breytenbach, Jaco C; du Preez, Jan L; du Plessis, Jeanetta.

Affiliation

Legoabe LJ; Unit for Drug Research and Development, North-West University, Potchefstroom, South Africa. lesetja.legoabe@nwu.ac.za

Drug Dev Ind Pharm ; 36(12): 1477-85, 2010 Dec.

Article in En | MEDLINE | ID: mdl-20560790

Subject(s)

Antimetabolites, Antineoplastic/chemical synthesis; Carbamates/chemical synthesis; Cytarabine/analogs & derivatives; Cytarabine/chemical synthesis; Polyethylene Glycols/chemistry; Skin/metabolism; Administration, Cutaneous; Antimetabolites, Antineoplastic/pharmacokinetics; Carbamates/pharmacokinetics; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cytarabine/pharmacokinetics; Female; Humans; In Vitro Techniques; Mass Spectrometry; Permeability; Skin Absorption/drug effects; Solubility

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Skin / Carbamates / Cytarabine / Antimetabolites, Antineoplastic Limits: Female / Humans Language: En Journal: Drug Dev Ind Pharm Year: 2010 Document type: Article

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