Cell adhesion: implication in tumor progression.

Zigler, M; Dobroff, A S; Bar-Eli, M

Zigler, M; Dobroff, A S; Bar-Eli, M.

Affiliation

Zigler M; Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Minerva Med ; 101(3): 149-62, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20562803

ABSTRACT

ABSTRACT

Changes in the adhesive properties of neoplastic cells, as well as intracellular signaling mediated by cell surface adhesion molecules, play essential roles in the development and progression of cancer. In this review, we summarize the recent progress in understanding the biology of cell adhesion molecules (CAMs) as well as their clinical significance as prognostic biomarkers or as potential therapeutic targets in a variety of malignancies.

Subject(s)

Cell Adhesion Molecules/physiology; Cell Adhesion/physiology; Neoplasm Proteins/physiology; Neoplasms/pathology; Antineoplastic Agents/therapeutic use; Cadherins/physiology; Cell Communication/physiology; Disease Progression; Humans; Immunoglobulins/physiology; Integrins/physiology; Neoplasms/drug therapy; Selectins/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Cell Adhesion Molecules / Cell Adhesion / Neoplasm Proteins / Neoplasms Limits: Humans Language: En Journal: Minerva Med Year: 2010 Document type: Article

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