Initial weight loss on an 800-kcal diet as a predictor of weight loss success after 8 weeks: the Diogenes study.
Eur J Clin Nutr
; 64(9): 994-9, 2010 Sep.
Article
in En
| MEDLINE
| ID: mdl-20588292
ABSTRACT
OBJECTIVE:
The purpose of this study was to investigate whether pre-treatment subject characteristics and weight change during the first weeks of a low-calorie diet (LCD) can predict weight loss outcomes at the end of a controlled 8-week weight loss period in overweight and obese adults.SUBJECTS:
A total of 932 overweight and obese subjects of both genders were included at eight European centers, and underwent an 8-week LCD period.RESULTS:
The weight loss at week 8 was positively correlated with initial body weight (Spearman's rho=0.62), height (rho=0.43), body mass index (rho=0.43), waist (rho=0.48) and hip circumference (rho=0.33), sagittal diameter (rho=0.45), fat mass (rho=0.35) and fat-free mass (rho=0.52), and gender (rho=-0.36) (all P<0.01). In the multivariate regression model, adjusted for center, only initial body weight, early weight loss (week 1) and weight loss at week 3 were significant predictors of weight loss outcome at week 8 weight loss (kg) at week 8=0.09+0.046 x baseline body weight (kg)-0.311 x weight loss (kg) at week 1+1.284 x weight loss (kg) at week 3 (R(2)=68%, P<0.0001). A weight loss of > or =2.6 kg at week 1 during the LCD period was identified as the optimal cut-off predictor for at least 10 kg weight loss at week 8.CONCLUSIONS:
This study suggests that initial body weight, early weight loss (week 1) and weight loss at week 3 are predictors of final weight loss during an 8-week LCD, and may be used as early biomarkers of subsequent responses to an LCD diet.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Weight Loss
/
Diet, Reducing
/
Overweight
/
Obesity
Type of study:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Eur J Clin Nutr
Year:
2010
Document type:
Article