AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3.

Wunderlich, M; Chou, F-S; Link, K A; Mizukawa, B; Perry, R L; Carroll, M; Mulloy, J C

Wunderlich, M; Chou, F-S; Link, K A; Mizukawa, B; Perry, R L; Carroll, M; Mulloy, J C.

Leukemia ; 24(10): 1785-8, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20686503

Subject(s)

Granulocyte-Macrophage Colony-Stimulating Factor/metabolism; Interleukin Receptor Common gamma Subunit/physiology; Interleukin-3/metabolism; Leukemia, Myeloid, Acute/metabolism; Stem Cell Factor/metabolism; Xenograft Model Antitumor Assays; Animals; Apoptosis/drug effects; Blotting, Western; Cell Proliferation/drug effects; Female; Flow Cytometry; Humans; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/pathology; Male; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; RNA, Messenger/genetics; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Granulocyte-Macrophage Colony-Stimulating Factor / Interleukin-3 / Stem Cell Factor / Xenograft Model Antitumor Assays / Interleukin Receptor Common gamma Subunit Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Leukemia Year: 2010 Document type: Article

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