Analysis of genomic breakpoints in p190 and p210 BCR-ABL indicate distinct mechanisms of formation.

Score, J; Calasanz, M J; Ottman, O; Pane, F; Yeh, R F; Sobrinho-Simões, M A; Kreil, S; Ward, D; Hidalgo-Curtis, C; Melo, J V; Wiemels, J; Nadel, B; Cross, N C P; Grand, F H

Score, J; Calasanz, M J; Ottman, O; Pane, F; Yeh, R F; Sobrinho-Simões, M A; Kreil, S; Ward, D; Hidalgo-Curtis, C; Melo, J V; Wiemels, J; Nadel, B; Cross, N C P; Grand, F H.

Affiliation

Score J; Wessex Regional Genetics Laboratory, Salisbury and Human Genetics Division, University of Southampton School of Medicine, Southampton, UK.

Leukemia ; 24(10): 1742-50, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20703256

Subject(s)

Chromosome Breakpoints; Fusion Proteins, bcr-abl/genetics; Genome, Human/genetics; Homeodomain Proteins/genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics; Base Sequence; Chromosomes, Human, Pair 22/genetics; Chromosomes, Human, Pair 9/genetics; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology; Molecular Sequence Data; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology; Prognosis; Sequence Homology, Nucleic Acid; Translocation, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Genome, Human / Fusion Proteins, bcr-abl / Homeodomain Proteins / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Chromosome Breakpoints Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: Leukemia Year: 2010 Document type: Article

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