Decitabine increases fetal hemoglobin in Papio anubis by increasing Î³-globin gene transcription.

Akpan, Imo; Banzon, Virryan; Ibanez, Vinzon; Vaitkus, Kestis; DeSimone, Joseph; Lavelle, Donald

Akpan, Imo; Banzon, Virryan; Ibanez, Vinzon; Vaitkus, Kestis; DeSimone, Joseph; Lavelle, Donald.

Affiliation

Akpan I; Department of Medicine, University of Illinois at Chicago, and Jesse Brown VA Medical Center, Chicago, IL 60612, USA.

Exp Hematol ; 38(11): 989-993.e1, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20713129

Subject(s)

Azacitidine/analogs & derivatives; Fetal Hemoglobin/genetics; gamma-Globins/genetics; Animals; Azacitidine/administration & dosage; Azacitidine/pharmacology; Chromatography, High Pressure Liquid; DNA Methylation/drug effects; Decitabine; Fetal Hemoglobin/metabolism; Papio; Promoter Regions, Genetic/genetics; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transcription, Genetic/drug effects; beta-Globins/genetics; beta-Globins/metabolism; epsilon-Globins/genetics; epsilon-Globins/metabolism; gamma-Globins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azacitidine / Fetal Hemoglobin / Gamma-Globins Limits: Animals Language: En Journal: Exp Hematol Year: 2010 Document type: Article

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