Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth.

Lin, Jianqing; Haffner, Michael C; Zhang, Yonggang; Lee, Byron H; Brennen, W Nathaniel; Britton, Justin; Kachhap, Sushant K; Shim, Joong Sup; Liu, Jun O; Nelson, William G; Yegnasubramanian, Srinivasan; Carducci, Michael A

Lin, Jianqing; Haffner, Michael C; Zhang, Yonggang; Lee, Byron H; Brennen, W Nathaniel; Britton, Justin; Kachhap, Sushant K; Shim, Joong Sup; Liu, Jun O; Nelson, William G; Yegnasubramanian, Srinivasan; Carducci, Michael A.

Affiliation

Lin J; Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

Prostate ; 71(4): 333-43, 2011 Mar 01.

Article in En | MEDLINE | ID: mdl-20809552

Subject(s)

DNA (Cytosine-5-)-Methyltransferases/antagonists & inhibitors; DNA Methylation; Disulfiram/pharmacology; Enzyme Inhibitors/pharmacology; Prostatic Neoplasms/drug therapy; Animals; Cell Line, Tumor; Cell Proliferation/drug effects; DNA (Cytosine-5-)-Methyltransferase 1; Humans; Male; Mice; Prostate-Specific Antigen/metabolism; Prostatic Neoplasms/genetics; Prostatic Neoplasms/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / DNA Methylation / Disulfiram / DNA (Cytosine-5-)-Methyltransferases / Enzyme Inhibitors Limits: Animals / Humans / Male Language: En Journal: Prostate Year: 2011 Document type: Article

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