Activation of PKC-alpha is required for migration of C6 glioma cells.
Acta Neurobiol Exp (Wars)
; 70(3): 239-45, 2010.
Article
in En
| MEDLINE
| ID: mdl-20871643
ABSTRACT
The PKC signaling pathway has been implicated in diverse cellular functions. Here, we sought to investigate the role of PKC-alpha÷beta in C6 glioma cell migration. We found that both PKC-alpha and PKC-beta were expressed by C6 glioma cells, but only PKC-alpha was markedly activated in serum-treated C6 cells. Go6976, a PKC-alpha÷beta specific inhibitor, was found to cause a dose-dependent reduction of PKC-alpha activation and cell migration induced by serum in C6 cells. These results collectively indicated that the PKC-alpha signaling pathway is necessary for glioma cell migration. Our findings may provide an insight into a better understanding to the malignant progression of gliomas.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Movement
/
Protein Kinase C-alpha
Limits:
Animals
Language:
En
Journal:
Acta Neurobiol Exp (Wars)
Year:
2010
Document type:
Article