Chromosomal assignment and physical linkage of the human C8 loci: implications regarding C8 polymorphisms and deficiencies.
Complement Inflamm
; 7(4-6): 298-301, 1990.
Article
in En
| MEDLINE
| ID: mdl-2088669
ABSTRACT
cDNA probes specific for the alpha, beta and gamma subunits of human C8 were used to establish that genes encoding alpha and beta are physically linked and in a 5' alpha-beta 3' orientation on chromosome 1. The gene encoding the gamma subunit was mapped to chromosome 9q. These results explain the close genetic linkage between alpha-gamma and beta on chromosome 1 and indicate that alpha-gamma polymorphisms detected in earlier genetic studies are determined solely by alpha. Results summarized in this report were presented at the VIth Complement Genetics Workshop and Conference (Mainz, FRG, 1989).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Chromosomes, Human, Pair 1
/
Chromosomes, Human, Pair 9
/
Complement C8
/
Genetic Linkage
Limits:
Humans
Language:
En
Journal:
Complement Inflamm
Year:
1990
Document type:
Article