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A concise and convergent synthesis of PA-824.
Marsini, Maurice A; Reider, Paul J; Sorensen, Erik J.
Affiliation
  • Marsini MA; Department of Chemistry, Frick Chemical Laboratory, Princeton University, Princeton, New Jersey 08544, United States.
J Org Chem ; 75(21): 7479-82, 2010 Nov 05.
Article in En | MEDLINE | ID: mdl-20929201
ABSTRACT
An efficient four-step synthesis of PA-824, a promising antituberculosis drug candidate, has been developed. This concise approach offers significant improvements over the synthetic route currently used for large-scale production.
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Nitroimidazoles / Antitubercular Agents Language: En Journal: J Org Chem Year: 2010 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Nitroimidazoles / Antitubercular Agents Language: En Journal: J Org Chem Year: 2010 Document type: Article