Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing different levels of estrogen receptor &#945; and ß.

Rossi, V; Bellastella, G; De Rosa, C; Abbondanza, C; Visconti, D; Maione, L; Chieffi, P; Della Ragione, F; Prezioso, D; De Bellis, A; Bellastella, A; Sinisi, A A

Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing different levels of estrogen receptor α and ß.

Rossi, V; Bellastella, G; De Rosa, C; Abbondanza, C; Visconti, D; Maione, L; Chieffi, P; Della Ragione, F; Prezioso, D; De Bellis, A; Bellastella, A; Sinisi, A A.

Affiliation

Rossi V; Dipartimento di Internistica Clinica e Sperimentale, Sezione di Endocrinologia ed Andrologia Medica, Universita' Federico II, Napoli, Italy.

J Cell Physiol ; 226(5): 1334-9, 2011 May.

Article in En | MEDLINE | ID: mdl-20945400

Subject(s)

Antineoplastic Agents, Hormonal/pharmacology; Apoptosis/drug effects; Cell Proliferation/drug effects; Estrogen Receptor alpha/drug effects; Estrogen Receptor beta/drug effects; Prostatic Neoplasms/pathology; Raloxifene Hydrochloride/pharmacology; Selective Estrogen Receptor Modulators/pharmacology; Signal Transduction/drug effects; Caspase 3/genetics; Caspase 3/metabolism; Cell Cycle/drug effects; Cell Line, Tumor; Dihydrotestosterone/pharmacology; Dose-Response Relationship, Drug; Enzyme Activation; Estradiol/pharmacology; Estrogen Receptor alpha/metabolism; Estrogen Receptor beta/metabolism; Gene Expression Regulation, Neoplastic/drug effects; Humans; Male; Metallothionein/genetics; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Phosphorylation; Prostatic Neoplasms/genetics; Prostatic Neoplasms/metabolism; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; Proto-Oncogene Proteins c-myc/genetics; RNA, Messenger/metabolism; Receptors, Thrombin/genetics; Receptors, Thrombin/metabolism; Time Factors; Transcription, Genetic/drug effects

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Prostatic Neoplasms / Signal Transduction / Apoptosis / Antineoplastic Agents, Hormonal / Raloxifene Hydrochloride / Selective Estrogen Receptor Modulators / Estrogen Receptor alpha / Estrogen Receptor beta / Cell Proliferation Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: J Cell Physiol Year: 2011 Document type: Article

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