Biomarkers, Tumor/biosynthesis; Gene Expression Regulation, Neoplastic; Lymphoma, Large B-Cell, Diffuse/metabolism; MicroRNAs/biosynthesis; NF-kappa B/metabolism; Neprilysin/biosynthesis; Proto-Oncogene Proteins/biosynthesis; Trans-Activators/biosynthesis; Animals; B-Lymphocytes/metabolism; Biomarkers, Tumor/genetics; CARD Signaling Adaptor Proteins; Cell Line, Transformed; Cell Line, Tumor; Chickens; Germinal Center/metabolism; Guanylate Cyclase; Humans; Lipopolysaccharides/pharmacology; Lymphocyte Activation/drug effects; Lymphocyte Activation/genetics; Lymphoma, Large B-Cell, Diffuse/diagnosis; Lymphoma, Large B-Cell, Diffuse/genetics; Lymphoma, Large B-Cell, Diffuse/therapy; MicroRNAs/genetics; Mutation; NF-kappa B/genetics; Neprilysin/genetics; Oncogene Proteins v-rel/genetics; Oncogene Proteins v-rel/metabolism; Prognosis; Promoter Regions, Genetic/genetics; Proto-Oncogene Proteins/genetics; Trans-Activators/genetics