Poorer perinatal outcome in male newborns of women with pregestational diabetes mellitus.
Diabet Med
; 28(4): 436-9, 2011 Apr.
Article
in En
| MEDLINE
| ID: mdl-21392065
ABSTRACT
AIMS:
To assess perinatal outcome in women with pregestational diabetes mellitus according to the sex of the fetus.METHODS:
A retrospective review of all singleton pregnancies of women with pregestational diabetes progressing to a gestational age of 22 weeks or more who attended the diabetes and pregnancy clinic from 1981 to 2006 (n=455). We compared maternal characteristics and perinatal outcomes (perinatal mortality, major congenital malformations, small and large for gestational age newborns, preterm birth and a composite of the former) according to the sex of the fetus. A logistic regression analysis was performed using the composite perinatal outcome as the dependent variable and all maternal variables and sex of fetus as potential predictors.RESULTS:
Maternal characteristics did not differ in mothers of male and female newborns. In the whole cohort, the composite perinatal outcome was significantly higher in male fetuses; adjusted OR 1.61 (95% CI 1.04-2.50).CONCLUSIONS:
In women with pregestational diabetes, perinatal outcome was poorer in male newborns despite similar maternal characteristics.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prediabetic State
/
Pregnancy Outcome
/
Sex Characteristics
/
Diabetes, Gestational
/
Diabetes Mellitus, Type 1
/
Diabetes Mellitus, Type 2
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
/
Newborn
/
Pregnancy
Language:
En
Journal:
Diabet Med
Year:
2011
Document type:
Article