Eight new alleles found in Flanders (Belgium), including the HLA-DRB1*12:24N allele.
Tissue Antigens
; 78(1): 45-8, 2011 Jul.
Article
in En
| MEDLINE
| ID: mdl-21457147
ABSTRACT
Human leukocyte antigen (HLA) high-resolution matching is routinely performed in the case of hematopoietic stem cell transplantation. Misdiagnosis of rare or new variants will result in additional unknown mismatches that can trigger graft versus host disease and/or graft failure. Using a mono allelic sequencing strategy, we obtained >90% first-step sequence-based high-resolution typing results, conforming to the standards set down by the European Federation for Immunogenetics. During this routine analysis, eight new HLA alleles were identified, including one DRB1*12 null variant, DRB1*1224N and three other coding mutants, resulting in a change of properties of the corresponding antigens.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HLA-DR Antigens
Type of study:
Prognostic_studies
Limits:
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Tissue Antigens
Year:
2011
Document type:
Article