The emerging role of autophagy in alcoholic liver disease.
Exp Biol Med (Maywood)
; 236(5): 546-56, 2011 May 01.
Article
in En
| MEDLINE
| ID: mdl-21478210
ABSTRACT
Autophagy is a highly conserved intracellular catabolic pathway that degrades cellular long-lived proteins and organelles. Autophagy is normally activated in response to nutrient deprivation and other stresses as a cell survival mechanism. Accumulating evidence indicates that autophagy plays a critical role in liver pathophysiology, in addition to maintaining hepatic energy and nutrient balance. Alcohol consumption causes hepatic metabolic changes, oxidative stress, accumulation of lipid droplets and damaged mitochondria; all of these can be regulated by autophagy. This review summarizes the recent findings about the role and mechanisms of autophagy in alcoholic liver disease (ALD), and the possible intervention for treating ALD by modulating autophagy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Liver Diseases, Alcoholic
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Exp Biol Med (Maywood)
Year:
2011
Document type:
Article