Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery.
Carbohydr Res
; 346(12): 1439-44, 2011 Sep 06.
Article
in En
| MEDLINE
| ID: mdl-21641587
A class of glycolipopeptides for use as building blocks for a new type of dynamic combinatorial library is reported. The members of the library consist of a variable carbohydrate moiety, coded amino acids, and lipoamino acids in order to convert them into amphiphiles. Glycolipopeptidic amphiphiles interact through non-covalent bonding when mixed together in aqueous phase and form micelles in dynamic close-packed fluid mosaic arrays. The head groups of amphiphiles are exposed on the micelle surface, providing entities which could be screened in biological assays to find the most potent combination of building blocks in order to identify new bioactive carbohydrate ligands.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Surface-Active Agents
/
Combinatorial Chemistry Techniques
/
Small Molecule Libraries
/
Drug Discovery
/
High-Throughput Screening Assays
Type of study:
Prognostic_studies
Language:
En
Journal:
Carbohydr Res
Year:
2011
Document type:
Article