Actomyosin-mediated cellular tension drives increased tissue stiffness and ß-catenin activation to induce epidermal hyperplasia and tumor growth.

Samuel, Michael S; Lopez, Jose I; McGhee, Ewan J; Croft, Daniel R; Strachan, David; Timpson, Paul; Munro, June; Schröder, Ewald; Zhou, Jing; Brunton, Valerie G; Barker, Nick; Clevers, Hans; Sansom, Owen J; Anderson, Kurt I; Weaver, Valerie M; Olson, Michael F

Samuel, Michael S; Lopez, Jose I; McGhee, Ewan J; Croft, Daniel R; Strachan, David; Timpson, Paul; Munro, June; Schröder, Ewald; Zhou, Jing; Brunton, Valerie G; Barker, Nick; Clevers, Hans; Sansom, Owen J; Anderson, Kurt I; Weaver, Valerie M; Olson, Michael F.

Affiliation

Samuel MS; Beatson Institute for Cancer Research, Glasgow, UK.

Cancer Cell ; 19(6): 776-91, 2011 Jun 14.

Article in En | MEDLINE | ID: mdl-21665151

Subject(s)

Actomyosin/physiology; Epidermis/pathology; Skin Neoplasms/etiology; beta Catenin/physiology; Animals; Biomechanical Phenomena; Cell Proliferation; Cells, Cultured; Humans; Hyperplasia; Mice; Papilloma/etiology; Signal Transduction; rho-Associated Kinases/analysis; rho-Associated Kinases/genetics; rho-Associated Kinases/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Actomyosin / Epidermis / Beta Catenin Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Cancer Cell Year: 2011 Document type: Article

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