An essential protective role of IL-10 in the immunological mechanism underlying resistance vs. susceptibility to lupus induction by dendritic cells and dying cells.

Ling, Guang-Sheng; Cook, H Terence; Botto, Marina; Lau, Yu-Lung; Huang, Fang-Ping

Ling, Guang-Sheng; Cook, H Terence; Botto, Marina; Lau, Yu-Lung; Huang, Fang-Ping.

Affiliation

Ling GS; Department of Medicine, Rheumatology Section, Division of Immunology and Inflammation, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

Rheumatology (Oxford) ; 50(10): 1773-84, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21727182

Subject(s)

Dendritic Cells/immunology; Immunity, Innate/immunology; Interleukin-10/physiology; Animals; Antibodies, Antinuclear/blood; Antibodies, Antinuclear/immunology; Apoptosis/immunology; Cells, Cultured; Coculture Techniques; Dendritic Cells/metabolism; Dendritic Cells/pathology; Disease Models, Animal; Disease Susceptibility/immunology; Down-Regulation; Interleukin-10/deficiency; Kidney/immunology; Kidney/pathology; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Knockout; Necrosis; Proteinuria/immunology; Proteinuria/pathology; Th1 Cells/immunology

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Dendritic Cells / Interleukin-10 / Immunity, Innate Type of study: Prognostic_studies Limits: Animals Language: En Journal: Rheumatology (Oxford) Year: 2011 Document type: Article

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