Phase IB study of sorafenib in combination with gemcitabine and cisplatin in patients with refractory solid tumors.

Schultheis, B; Kummer, G; Zeth, M; Brendel, E; Xia, C; Kornacker, M; Strumberg, D

Schultheis, B; Kummer, G; Zeth, M; Brendel, E; Xia, C; Kornacker, M; Strumberg, D.

Affiliation

Schultheis B; Department of Haematology and Medical Oncology, University of Bochum (Marienhospital Herne), Hoelkeskampring 40, 44625 Herne, Germany. beate.schultheis@marienhospital-herne.de

Cancer Chemother Pharmacol ; 69(2): 333-9, 2012 Feb.

Article in En | MEDLINE | ID: mdl-21735354

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Neoplasms/drug therapy; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics; Area Under Curve; Benzenesulfonates/administration & dosage; Benzenesulfonates/adverse effects; Benzenesulfonates/pharmacokinetics; Cisplatin/administration & dosage; Cisplatin/adverse effects; Cisplatin/pharmacokinetics; Deoxycytidine/administration & dosage; Deoxycytidine/adverse effects; Deoxycytidine/analogs & derivatives; Deoxycytidine/pharmacokinetics; Drug Administration Schedule; Drug Resistance, Neoplasm/drug effects; Gastrointestinal Diseases/chemically induced; Hematologic Diseases/chemically induced; Humans; Metabolic Clearance Rate; Middle Aged; Neoplasms/metabolism; Neoplasms/pathology; Niacinamide/analogs & derivatives; Phenylurea Compounds; Pyridines/administration & dosage; Pyridines/adverse effects; Pyridines/pharmacokinetics; Skin Diseases/chemically induced; Sorafenib; Treatment Outcome; Gemcitabine

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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Neoplasms Type of study: Guideline / Prognostic_studies Language: En Journal: Cancer Chemother Pharmacol Year: 2012 Document type: Article

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